Vermixocins A and B, two novel metabolites from Penicillium vermiculatum.
نویسندگان
چکیده
Vermixocins A and B, 3-(1'-hydroxy-3'-methylbutyl)- and 3-(1'-acetoxy-3'-methylbutyl)-11-hydroxy-4-methoxy-9-methyl-5H,7H- dibenzo[c,f][1,5]dioxocin-5-one, respectively, were isolated from the mycelium of Penicillium vermiculatum. Both metabolites showed cytotoxic effects on lympholeukemia cells P388.
منابع مشابه
Extracellular polysaccharides of Penicillium vermiculatum.
Extracellular Polysaccharide, Isolation, Characterization Extracellular polysaccharide mixture that forms a viscous mucilate in the fermentation medium during industrial cultivation of Penicillium vermiculatum was isolated by ethanol precipitation and its structural characteristics were investigated by a combination of physicochemical methods. The mixture contained two structurally different po...
متن کاملIdentification of some secondary metabolites produced by four Penicillium species
Fungi produce a wide range of secondary metabolites such as antibiotics, toxins, alkaloids, fatty acids, ketones and alcohols during active cell growth. The present study was aimed to identify secondary metabolites from some Penicillium species, using GC-MS. Many important compounds such as 3-oxoquinuclidine in Penicillium jenseii, formamidine in Penicillium pusillum, orcinol and 1,3,8-p-mentha...
متن کاملThe structure of vermistatin, a new metabolite from Penicillium vermiculatum.
Separation of metabolites of Penicillium vermiculatum DANG present in the cultivation medium afforded three new antibiotics; vermiculinel), vermistatin2) and vermicillin3) . The structure of vermiculine, a macrolide dilactone has already been solved by X-ray diffraction analysis". This paper presents the structure elucidation of the second compound of this series, vermistatin. In our previous p...
متن کاملSynthesis and Biotransformation of Bicyclic Unsaturated Lactones with Three or Four Methyl Groups.
The aim of this study was to obtain new unsaturated lactones by chemical synthesis and their microbial transformations using fungal strains. Some of these strains were able to transform unsaturated lactones into different hydroxy or epoxy derivatives. Strains of Syncephalastrum racemosum and Absidia cylindrospora gave products with a hydroxy group introduced into a tertiary carbon, while the Pe...
متن کاملNovel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin.
Two new indolic metabolites were isolated from Penicillium crustosum and separated from other penitrem mycotoxins by high-performance liquid chromatography. Penitrem D is a deoxy-penitrem A. Penitrem E is dechloro-penitrem A and was shown to be tremorgenic in mice, although it has only one-third of the activity of penitrem A. Roquefortine was also shown, for the first time, to be an important m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 45 8 شماره
صفحات -
تاریخ انتشار 1992